Recombinant Human Cartilage Intermediate Layer Protein 1 (CILP), Partial MBS7115190 from MyBioSource.com

Description

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage

Product Specs
ItemRecombinant Human Cartilage Intermediate Layer Protein 1 (CILP), Partial
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS7115190
Quantity0.01 mg (Baculovirus)
FormatTris-Based Buffer, 50% Glycerol
Molecular Weight55.7 kDa
Purity>85% as determined by SDS-PAGE
NCBI Full Gene Namecartilage intermediate layer protein
NCBI Gene AliasesCILP-1, HsT18872
Molecule NameCartilage Intermediate Layer Protein 1 (CILP)
TypeRecombinant Protein
Domain/Region/Terminus725-1184aa; Partial
Source/Expression SystemBaculovirus

Sequence

EDRTFLVGNL EIRERRLFNL DVPESRRCFV KVRAYRSERF LPSEQIQGVV ISVINLEPRT GFLSNPRAWG RFDSVITGPN GACVPAFCDD QSPDAYSAYV LASLAGEELQ AVESSPKFNP NAIGVPQPYL NKLNYRRTDH EDPRVKKTAF QISMAKPRPN SAEESNGPIY AFENLRACEE APPSAAHFRF YQIEGDRYDY NTVPFNEDDP MSWTEDYLAW WPKPMEFRAC YIKVKIVGPL EVNVRSRNMG GTHRQTVGKL YGIRDVRSTR DRDQPNVSAA CLEFKCSGML YDQDRVDRTL VKVIPQGSCR RASVNPMLHE YLVNHLPLAV NNDTSEYTML APLDPLGHNY GIYTVTDQDP RTAKEIALGR CFDGTSDGSS RIMKSNVGVA LTFNCVERQV GRQSAFQYLQ STPAQSPAAG TVQGRVPSRR QQRASRGGQR QGGVVASLRF PRVAQQPLIN

Specifications/Features

Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses

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